CAMO Software
Home > News & Events > Press Release > Correlation Optimized Warping (COW) algorithm for The Unscrambler®

The Unscrambler® now adds Correlation Optimized Warping (COW) to its Pre-processing Options.

The Unscrambler® 9.8 a leading multivariate analytical software, will now be available with the Correlation Optimized Warping (COW) as one of its pre-processing options. Existing users of The Unscrambler® 9.8 can apply this option to align their chromatographic and Nuclear Magnetic Resonance (NMR) data types.

Correlation Optimised Warping (COW) for The Unscrambler® 9.8
Correlation Optimized Warping
for The Unscrambler®

Oslo, Norway - Aug 04, 2009: Addressing the needs of the customers has been at the forefront of CAMO Software’s business philosophy and in response to the increasing use of multivariate methods applied to chromatographic and Nuclear Magnetic Resonance (NMR) data, The Unscrambler® now provides the Correlation Optimization Warping (COW) pre-processing algorithm for aligning these data types.

COW aligns shifted data, such as chromatograms or NMR spectra, by means of sequential, segmental linear stretching and compression routine in order to best correlate new data to a reference chromatogram or spectrum. The first step is to divide the data up into a specified number of segments. The new data is warped to match the same section of the reference data. A second parameter, called the slack is defined so as to allow sufficient movement of the segment to allow the greatest possible flexibility during the warping.

The introduction of COW is a significant step for CAMO Software for the analysis of chromatographic and NMR data”, explains Brad Swarbrick, Product Manager for CAMO Software AS, “It provides an essential tool for Metabolomics and process chromatographic/ NMR users for removing the systematic effects of axis shift, allowing multivariate classification methods to be more specific to real chemical and biological changes in collected data”.

Data before the application of the pre-processing algorithm   Data after the application of Correlation Optimised Warping (COW) algorithm
Data before and after the application of the COW algorithm.


COW is the first of CAMO’s shift modeling offerings and is available now for version 9.8 users. “COW is appropriate for peak shifts in chromatography, and in future releases, we will also have algorithms that handle peak stretching while preserving the peak areas, so look out in the future for a complete shift modeling plug in for soon-to-be released "The Unscrambler® X” explains Frank Westad, Chief Scientific Officer for CAMO Software AS.

Existing users of The Unscrambler® 9.8 may apply the Correlation Optimized Warping (COW) installable. The COW option is placed in the User Defined Transforms of the Modify menu. For more information, visit or contact your CAMO representative.



About CAMO

Headquartered in Oslo, Norway, CAMO Software is a leading scientific and sensory software development company offering a complete range of multivariate data analysis solutions, which can be used to assist to implement a process of analytical technology (PAT) and quality by design (QbD) into their facilities.

For further press information, please visit