The Unscrambler®: Comprehensive Multivariate Analysis and Experimental Software

+ Flexible
+ Adaptable
+ Multivariate Technology
+ Security

project based data organization - Flexibility to organise your data & analyse into projects
- Flexibility with licensing options
- Flexible in customization of
The Unscrambler® with plugin options

modular plug-in architecture Adaptable to the needs of the many different scientific disciplines through the incorporation of application specific plug-ins. Incorporate The Unscrambler® models into 3rd party applications.

methods & algorithms Support vector machine classification and L-PLS, the classical hierarchical cluster analysis and linear discriminant analysis, which widen our scope to metabolomics, sensometrics and process monitoring.

Password access, windows domain authentication and audit trails provide the necessary security requirements for the regulated environment.

The Unscrambler® X ( a GenX suite of products ) represents the single largest redesign of CAMO Software’s flagship product The Unscrambler®. Featuring an enhanced user friendly interface, superior graphics and new state-of-the-art methods, The Unscrambler® X provides the most flexible and adaptable approach to Multivariate Data Analysis (MVA) and Design of Experiments (DoE) available. The Unscrambler® X reaches out to a wider audience of data analysts, and process control applications, while still maintaining a strong commitment to our spectroscopic & sensory data analysis users.

Spectroscopic & Sensory Data		Design of Experiments
The analysis of spectroscopic and sensory data represent key applications of The Unscrambler® X more...		Define - Design - Analyse - Improve. DoE can be used to minimise costs leading to faster ROI more...

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Benefits
Features
Industries
What's new



Better understand your products and processes through designed experiments and multivariate modelling.	Maximize the benefits of The Unscrambler® models by using them in conjunction with our 3rd party partners, software platforms and instrumentation. more...


Smarter designs use less resources and result in more information. Use this information to eliminate unnecessary measurements and maximize ROI	Measure only what is critical to quality by using The Unscrambler® models for Multivariate Statistical Process Control (MSPC) applications

Descriptive Statistics

Mean/ Std Dev/ Quartiles/ Cross Correlations/ Scatter Effects

Statistical Tests

Normality Test/ t-Tests/ F-Tests/ Mardia’s Multivariate Test

Cluster Analysis

K-means / K-medians Ward’s method

Hierarchical Cluster Analysis (HCA) with dendrograms

Principal Component Analysis (PCA)

Choice of using NIPALS or SVD algorithms

Rotation methods including Varimax, Equimax, Quartimax and Parsimax

Multivariate Curve Resolution (MCR)

Resolve time evolving data such as chemical reaction or chromatographic data into pure constituent profiles and pure spectra

Regression Methods

Multiple Linear Regression (MLR) / Principal Component Regression (PCR) and Partial Least Squares Regression (PLSR)

Choice of algorithms, NIPALS and SVD for PCR and NIPALS, Kernel Methods and Orthogonal Scores for PLSR
Improved Test Set Validation options

Q-Residuals in influence plots
L-PLS, incorporating three data tables for greater insights into data structure

Advanced Classification Methods

Projection using PCA and PLS models

Soft Independent Modelling of Class Analogy (SIMCA) now also incorporating PLS models

Linear Discriminant Analysis (LDA)

Support Vector Machines (SVM) Classification with numerous kernel types

Spectral Functions

Smoothing

Derivatives: Moving Average/ Norris Gap/ Savitzky-Golay

Baseline Correction

Normalization

Spectroscopic: Reflectance/ Transmission/ Kubelka-Munck

Scatter Correction and Advanced Functions

Multiplicative and Extended Multiplicative Scatter Correction (MSC/ EMSC)

Standard Normal Variate (SNV)

Deresolve

Detrending

General Transforms

Improved Centre and Scale options

Spectroscopic: Reflectance/ Transmission/ Kubelka-Munck

Interaction & Squares and Individual Variable Weighting

Compute General

Fill Missing Values

Correlation Optimization Warping (COW)

Improved Design Wizard

Interactive design setup with full descriptions and Beginner/ Expert modes

Complete range of full and fractional factorial designs

Enhanced optimization designs including Central Composite (CCD) and Box-Behnken (BB) designs

Enhanced mixture designs including Axial, Simplex Lattice and Simplex Centroid designs

Choice of Analysis Algorithms

Classical MLR and ANOVA-PLS for non-orthogonal designs

PLSR or Scheffe Polynomials for mixture designs

Comprehensive Analysis Overview

ANOVA tables and other tabular results

Cube Plots

Response Surfaces

Analysis of Effects

Interactive Tables


Pharmaceuticals Classify raw materials and better understand their properties using exploratory data analysis Incorporate The Unscrambler® models with NIR spectrometers to determine end points of blending, drying and coating processes Use The Unscrambler® developed models with analytical laboratory based instruments to determine the moisture or active content in lyophillised or solid dose products MVA and DoE form one of the four key aspects of the Process Analytical Technology (PAT) initiative. Determine the parameters that are critical to quality with The Unscrambler® and build your processes using Quality by Design (QbD)


Energy Use multivariate models and NIR spectroscopy to monitor gasoline blending operations Design new materials for wind generators and other renewable energy applications Monitor coal quality online using multivariate models incorporating infrared spectroscopy and process equipment outputs Use Principal Component Analysis (PCA) for locating new oil reserves based on geochemical data


Chemicals Optimise paint and other polymer based products and processes with process-mixture designs Design new semi-conductor materials 4Use process outputs and other measurement equipment to monitor the quality of fertiliser production with multivariate process models Improve paper and pulp operations by measuring critical raw material feeds and liquors Use predictive modelling with process spectrometers to assess quality attributes of high value commodities during the progress of chemical reactions


Food & Beverages Formulate new food and beverage products using designed experiments according to consumer segment requests Target key markets using cluster analysis and consumer segmentation Use The Unscrambler® to Optimise baking times for pastry products Blend the best combination of wines based on preference and cost Improve the look and texture of new and existing products based on trained sensory panel evaluations Reengineer competitive products

Project based data organisation

The user interface has been reviewed to help organize data and analyses into projects. Each data set, analysis result and associated plots are displayed as nodes in a tree structure to provide simpler and faster ways to browse the right information and use it.

Easy data import

Getting data into The Unscrambler® X is the first step of any analysis. We have made it simple & intuitive and you can preview only the data you want to import. Sample and variable names are attributed automatically. Preview works for both spreadsheet data and spectroscopic data.

Interactive pretreatments

Finding appropriate transformation parameters can be time-consuming. Real-time preview of results will help you find the right parameters in a shorter time, as the pretreatment is being performed. A new matrix is generated, keeping the original data intact and allowing comparison and reversion.

Superior data visualisation

The Unscrambler® X provides a whole range of graphical tools to get the best visual representation of your data. You can style charts and draw lines, marks and add text to annotate them. Copy and paste plot graphics into documents or save in common picture formats.

Windows domain authentication

The Unscrambler® X now can be set up to accept user credentials as login, or enter a predefined user name and password. This system of login is compliant with the requirements of electronic signatures and records required by the US FDA. The Audit Trail system has been greatly improved.

L-PLS, HCA, SVM and LDA algorithms

L-PLS, LDA, SVM are powerful new methods for analyzing and classical statistical approach to classification, included in The Unscrambler® X. It also contains improved K-Means analysis, HCA with dendrograms, Ward’s Methods etc

Improved calculation efficiency & performance

With The Unscrambler® X, Get more information from fewer experiments, Faster calculations , Maintain Forward compatibility of all data and model files, which can be used in real-time via Unscrambler Online and with Unscrambler Predictor (OLUP)/ Unscrambler Classifier (OLUC).

Basic statistical tests

The Basic Statistical Tests functionality provides some of the most commonly used statistical tests for comparing two sample sets. They include: KS and Mardia's test, Student's t test, Paired t test, Levene's, Barlett's and F test.

Report generator

Report generator generates customized reports with options to choose settings for page setup, report content, preview and security. All reports can be saved in PDF format.


The Unscrambler® X is the first all-in-one multivariate data analysis and design of experiments software to go 64-bit. The 64-bit version of The Unscrambler® X not only runs faster, it is also more secure. That's because 64-bit applications can use more advanced security techniques.	The 21CFR part 11 document provides guidance to industry on how to address the requirements of electronic signatures and audit trails. The Unscrambler® X is compliant to the requirements of part 11, supporting windows domain authentication, audit trailing, tracking failed actions and monitoring attempts to change user rights, privileges and passwords.	OPC (originally OLE for process control) is an industry standard developed in collaboration of a number of leading hardware and software vendors. The OPC-DA is a non-proprietary technical specification that defines a set of standard interfaces based upon Microsoft’s OLE/COM/DCOM platform and .NET technology. The application of the OPC standard interface enables the interoperability of automation, control applications, field devices and business applications. The Unscrambler® X now enables users to successfully interoperate with the various OPC products available.